Gallery owner and educator Martha (Marti) Koplin opened Koplin Gallery in West Hollywood, California, in January 1982 with an exhibition of Joan Brown's sculptures and paintings, and constructions by Elena and Mary Siff. Koplin Gallery subsequently played an active role in the Los Angeles gallery and art scene mounting an eclectic range of exhibitions showing photography, sculpture, representational works, and abstract art.
In 1990 the gallery moved to Santa Monica before returning to West Hollywood in 1996. Eleana Del Rio joined the gallery in 1989 and became a principle in the gallery in 1998. By that time Koplin Gallery had become the representative of Rico Lebrun's estate and showed artists such as Darlene Campbell, James Doolin, Martha Mayer Erlebacher, Mineko Grimmer, Kerry James Marshall, and others. Martha Koplin retired in 2002 and formally announced the inauguration of the Koplin Del Rio gallery in 2003 with Eleana Del Rio as the director. Del Rio continues to operate Koplin Del Rio Gallery in Seattle, Washington.